Eyes on chromosomes.

Eyes on chromosomes.

Another passenger on chromosomes

A synaptic scaffold quiets T cells scaffolding protein at neuronal synapses has found its way to another kind of synapse—the immune synapse, which forms at the interface between antigen presenting cells and T cells. As shown by Xavier et al. on page 173, this multi-domain protein, called Dlg1, tempers the activity of both types of synapses. On the T cell side of the immune syn-apse, activated T...

Eyes on systems pharmacology.

As an emerging subdiscipline of pharmacology, one of the priary goals of systems pharmacology is to elucidate therapeutic echanisms of combined pharmacological strategies used to treat iverse complex diseases in which multiple integrated cellular athways are perturbed. Mechanistic insights into disease pathogenesis are critical for ptimal therapeutic development. With the exception of rare onoo...

Eyes on the Vulnerable.

Keep Eyes on Integrins

In mammals, there are 18 kinds of α subunit and 8 kinds of β subunit were discovered, which form 24 combinations (Table 1) [2,3]. Overall, these 24 kinds of integrins can be divided to two groups by containing α-I domain (Table 1 and Figure 1A) or not (Table 1 and Figure 1B). Integrin can regulate its ligand-binding affinity by conformational changes [1]. The adaptor proteins and signal pathway...